阿爾茲海默�。ˋlzheimer’sdisease,AD）是最常見(jiàn)的神經(jīng)退行性疾病，是全球最具挑戰(zhàn)的攻堅(jiān)課題之一。AD根據(jù)臨床表現(xiàn)可以分為臨床前期和癥狀期。淀粉樣蛋白（Aβ）沉積出現(xiàn)在臨床前病理期，比癥狀期早15-20年。對(duì)比之下，神經(jīng)原纖維纏結(jié)（Tautangle）起始于癥狀期，并與神經(jīng)元死亡和腦萎縮發(fā)生的時(shí)間高度重合。
實(shí)驗(yàn)室負(fù)責(zé)人陳曉穎博士通過(guò)系統(tǒng)分析Aβ和Tau兩種AD模型，結(jié)合病人腦組織樣本，首次發(fā)現(xiàn)在AD的發(fā)生發(fā)展中，大腦存在固有免疫和獲得性免疫相互促進(jìn)的異常免疫應(yīng)答，打破這一異常免疫應(yīng)答中的任何一個(gè)環(huán)節(jié)將有望能延緩或逆轉(zhuǎn)AD晚期病理改變。相關(guān)工作以長(zhǎng)文形式發(fā)表于Nature，并同期被Nature和Natureaging高亮點(diǎn)評(píng)。這一研究揭示了神經(jīng)免疫微環(huán)境的組成特點(diǎn)及其在疾病中的動(dòng)態(tài)演變，為理解神經(jīng)退行性疾病的發(fā)病機(jī)制提供了新的理論基礎(chǔ)，對(duì)神經(jīng)退行性病變的干預(yù)提供了全新的視角和手段。
作為清華大學(xué)免疫中心/麥戈文/清北生命聯(lián)合中心獨(dú)立PI，陳曉穎博士實(shí)驗(yàn)室建設(shè)有完善的動(dòng)物模型平臺(tái)、單分子平臺(tái)和成像空間，將聚焦于神經(jīng)免疫和代謝在學(xué)習(xí)記憶與神經(jīng)退行疾病中的作用機(jī)制，并探索神經(jīng)退行疾病的干預(yù)策略。
Dr. Chen is a Principal Investigator and an associate professor of Institute for Immunology at Tsinghua University School of Medicine, Mc Govern Institute as well as Tsinghua-Peking Center for Life Science. Chen lab focuses on understanding the brain-immune interactions in health and disease. The major research directions in her lab are 1) decoding the immune responses in Alzheimer’s disease and therapeutics development, 2) deciphering brain-immune interface and brain-body interaction, and 3) understanding neuronal plasticity throughout AD progression.
神經(jīng)免疫課題組負(fù)責(zé)人介紹
陳曉穎博士先后在加州大學(xué)洛杉磯分校和華盛頓大學(xué)醫(yī)學(xué)院從事科學(xué)研究工作，師從華盛頓大學(xué)醫(yī)學(xué)院前神經(jīng)科學(xué)系主任Azad Bonni教授（美國(guó)醫(yī)學(xué)院士， 現(xiàn)任瑞典羅氏總部副總裁）和神經(jīng)病學(xué)系主任David Holtzman 教授（美國(guó)醫(yī)學(xué)院士，前美國(guó)神經(jīng)協(xié)會(huì)主席），并和免疫系Marco Colonna 教授（美國(guó)科學(xué)院院士），Ken Murphy教授（免疫學(xué)教科書作者），Jonny Kipnis教授（腦膜免疫的開(kāi)創(chuàng)者）和哈佛醫(yī)學(xué)院再生醫(yī)學(xué)系Rudy Tanzi教授（衰老中心主任）, Jorfi, Mehdi教授等有深入的國(guó)際合作。
陳曉穎博士是阿爾茲海默�。ˋD）研究領(lǐng)域的杰出青年科學(xué)家之一，其研究成果促使領(lǐng)域內(nèi)重新認(rèn)識(shí)了外周適應(yīng)性免疫在重構(gòu)疾病相關(guān)中樞炎癥以及疾病發(fā)生發(fā)展中的核心作用，并據(jù)此提出干預(yù)AD新的治療方向。陳曉穎博士創(chuàng)新性科研成果發(fā)表于Nature （2022年，2023年）等頂級(jí)期刊，受到廣泛關(guān)注。鑒于其學(xué)術(shù)貢獻(xiàn)，陳曉穎博士近幾年來(lái)被授予了AD研究的諸多國(guó)際大獎(jiǎng), 獲Cure Alz foundation 的Jeffrey L. Morby 獎(jiǎng)（年度最影響力研究）, 獲國(guó)際阿爾茲海默病協(xié)會(huì)（Alzheimer Association）早期職業(yè)成就獎(jiǎng)(封面), 受邀在阿爾茲海默病大會(huì)做報(bào)告，代表女性科學(xué)家發(fā)言; 獲華盛頓大學(xué)年度神經(jīng)科學(xué)最佳研究獎(jiǎng)；神經(jīng)科學(xué)年會(huì)（Sfn）職業(yè)發(fā)展獎(jiǎng)；受Immunity 邀請(qǐng)針對(duì)神經(jīng)免疫領(lǐng)域進(jìn)行綜述和展望。因后續(xù)影響力，相關(guān)研究還被邀請(qǐng)?jiān)贙eystone, AAI, Cell, NIH 50-year Grant Proposal Meeting, Cold Spring Harbor Meeting 等國(guó)際大會(huì), 在UCSF, Cornell, WashU, NIH等大學(xué)和研究機(jī)構(gòu)，在JBP Foundation, Alzheimer's Association Foundation, Alzheimer’s Research Trust Foundation等基金會(huì)作口頭報(bào)告。Dr. Chen was a faculty member in the Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center at Washington University School of Medicine. She has contributed significant insights into understanding neuronal plasticity during development (Chen., et al., 2017, Journal of Neuroscience; Chen., et al., 2016, 2020, Protein & Cell), learning activities (Chen., et al., 2022, Nature), and neuron-immune interactions in neurodegenerative disease (Chen., et al., 2022, Immunity; Chen., et al., 2023, Nature). She has received a number of honors and awards, including the O’Leary Prize for Best Neuroscience Research at Washington University, the Poletsky Award for Alzheimer’s Disease Research from Washington University, the Tau Consortium Fellowship from Rainwater Charitable Foundation, the Coins for Alzheimer’s Research Trust from Rotary Foundation, the Career Development Award from the Society for Neuroscience, the Early Career Achievement Award from Alzheimer’s Association, and the Jeffrey L. Morby Prize for Best Research in Alzheimer’s Disease from Cure Alzheimer’s Fund. She is a member of Society for Neuroscience, Alzheimer’s Association, American Society for Neurochemistry, American Neurological Association and International Society for Molecular Neurodegeneration. Dr. Chen has reviewed papers for journals, including Immunity, Nature Neuroscience, Alzheimer's & Dementia, Science Advances, Cell Reports, Molecular Neurodegeneration, Journal of Clinical Investigation, Journal of Neuroimmunology (Editorial board member), and Translational Neurodegeneration.
實(shí)驗(yàn)室招聘博士后
崗位要求與福利待遇：
實(shí)驗(yàn)室基本要求：團(tuán)結(jié)互助，責(zé)任心強(qiáng)，視野開(kāi)闊，有批判精神，學(xué)術(shù)誠(chéng)信。
博士后要求：招聘免疫學(xué)、神經(jīng)生物學(xué)或生物信息學(xué)背景博士后，能在導(dǎo)師指導(dǎo)下獨(dú)立從事神經(jīng)免疫課題研究。具有免疫學(xué)、系統(tǒng)神經(jīng)生物學(xué)、分子生物學(xué)、單細(xì)胞組學(xué)、成像、基因編輯、生物信息學(xué)經(jīng)驗(yàn)者優(yōu)先。已獲或者即將獲博士學(xué)位。
博士后待遇：在國(guó)家和清華大學(xué)規(guī)定的工作和生活待遇外，根據(jù)個(gè)人能力和工作經(jīng)驗(yàn)給予具有競(jìng)爭(zhēng)力的津貼，并支持申請(qǐng)國(guó)家“博新計(jì)劃”、清華“水木學(xué)者”、以及生命科學(xué)聯(lián)合中心博士后支持計(jì)劃和各類基金。
請(qǐng)發(fā)送郵件至： xiaoyingchen36@gmail.com。博后申請(qǐng)人除發(fā)送個(gè)人簡(jiǎn)歷外，附加學(xué)術(shù)成果介紹，課題計(jì)劃和三名推薦人聯(lián)系方式。
Lab members.
Highly motivated Postdoctoral Fellows in the field of Immunology, Neuroscience and Bioinformatics.
-Ph.D or M.D who have proven record of high-quality publications, experiences with immunology, system neuroscience, molecular biology, single-cell, in vivo calcium imaging, optogenetics, CRISPR or bioinformatics are preferred.
-Strong interests in working with multidisciplinary teams.
To apply,
Please send your CV, cover letter, research accomplishments, future research interests/plans, and 3 references, including their names, emails, and phone numbers to xiaoyingchen36@gmail.com. Please avoid sending compressed Zip files.
Nature|陳曉穎等揭示固有免疫和獲得性免疫在阿爾茲海默病中的關(guān)鍵致病機(jī)理
Nature|建立神經(jīng)元功能多樣性解析方法并揭示可塑性浦肯野神經(jīng)元及其學(xué)習(xí)記憶機(jī)理
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