中心簡介

首都醫(yī)學(xué)科學(xué)創(chuàng)新中心（簡稱創(chuàng)新中心）是北京市新成立的具有獨(dú)立法人資格的新型研發(fā)機(jī)構(gòu)。創(chuàng)新中心以推動(dòng)醫(yī)學(xué)科學(xué)發(fā)展、改善人類健康為目標(biāo)，開展生物醫(yī)學(xué)研究，致力于提升醫(yī)學(xué)科學(xué)創(chuàng)新與成果轉(zhuǎn)化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學(xué)家，與首都醫(yī)學(xué)教育和科學(xué)研究優(yōu)質(zhì)資源緊密合作，打造多學(xué)科交叉融合的科研平臺(tái)，綜合自由探索、醫(yī)學(xué)目標(biāo)導(dǎo)向、有組織科研等途徑，實(shí)踐新型科研模式和體制機(jī)制，逐步推進(jìn)醫(yī)教研產(chǎn)的深度融合，培養(yǎng)適應(yīng)醫(yī)學(xué)科學(xué)創(chuàng)新發(fā)展的優(yōu)秀人才。

實(shí)驗(yàn)室介紹

王宇濤實(shí)驗(yàn)室現(xiàn)面向國內(nèi)外招聘博士后與科研助理！實(shí)驗(yàn)室致力于研究感染、炎癥及腫瘤發(fā)展的免疫調(diào)控機(jī)制，重點(diǎn)關(guān)注核受體家族在病毒感染、腫瘤免疫及免疫應(yīng)答性別差異中的關(guān)鍵作用，同時(shí)結(jié)合小分子藥物開發(fā)和合成生物學(xué)工具，探索并推動(dòng)新型疾病治療策略的研發(fā)與轉(zhuǎn)化應(yīng)用。實(shí)驗(yàn)室擁有前沿且具有挑戰(zhàn)性的研究方向、完善的科研平臺(tái)、充足的經(jīng)費(fèi)支持與友好開放的科研氛圍，重視每一位成員的成長與發(fā)展。如果你渴望在一個(gè)積極向上、合作融洽的團(tuán)隊(duì)中，探索生命科學(xué)的前沿問題，收獲專業(yè)能力與成長快樂，歡迎加入我們！

王宇濤研究員本科畢業(yè)于蘭州大學(xué)，博士畢業(yè)于北京大學(xué)，師從蔣爭凡教授，博士期間研究工作揭示了Caspase家族成員在天然免疫穩(wěn)態(tài)和維持細(xì)胞凋亡免疫沉默中的調(diào)控作用；之后在哈佛醫(yī)學(xué)院Christophe Benoist和Diane Mathis實(shí)驗(yàn)室完成博士后訓(xùn)練，運(yùn)用體內(nèi)高通量Rainbow-CRISPR篩選系統(tǒng)研究核受體家族在免疫細(xì)胞分化與細(xì)胞命運(yùn)調(diào)控中的作用。王宇濤研究員將于2025年6月正式加入首都醫(yī)學(xué)科學(xué)創(chuàng)新中心。

主要研究方向

1.核受體在病毒誘導(dǎo)的代謝重編程和天然免疫應(yīng)答中的調(diào)控機(jī)制。

2.核受體在腫瘤進(jìn)展與抗腫瘤免疫調(diào)控中的作用及其治療潛力。

3.核受體介導(dǎo)免疫應(yīng)答性別差異的分子機(jī)制研究。

4.基于合成生物學(xué)的轉(zhuǎn)錄因子活性檢測(cè)和精準(zhǔn)治療策略開發(fā)。

主要成果與貢獻(xiàn)

1. 建立體內(nèi)高通量“Rainbow-CRISPR”篩選系統(tǒng)，系統(tǒng)解析核受體家族成員在免疫細(xì)胞分化和穩(wěn)態(tài)維持中的作用，揭示視黃酸受體通過轉(zhuǎn)錄調(diào)控和炎癥小體活化雙重機(jī)制調(diào)控GATA6⁺腹腔巨噬細(xì)胞命運(yùn)（Immunity，2024，一作）。

2. 揭示TRAF6介導(dǎo)的ASK1 Lys6-連接的多聚泛素化修飾在肝臟炎癥和纖維化的關(guān)鍵作用（Hepatology，2019，一作）；發(fā)現(xiàn)NLK激酶是抑制肝糖異生的關(guān)鍵分子，揭示血糖穩(wěn)態(tài)調(diào)控的新機(jī)制（Cell Metabolism，2021，并列一作）。

3. 闡明Caspase家族成員在抗病毒天然免疫穩(wěn)態(tài)和維持細(xì)胞凋亡免疫沉默中的調(diào)控作用（Immunity，2017，一作；Molecular Cell，2019，并列一作）。

代表性文章

Wang et al., 2024, Immunity, PMID: 39571575

Ji, Wang et al., 2021, Cell Metabolism, PMID: 33951476

Wang et al., 2020, Hepatology, PMID: 31222801

Ning, Wang et al., 2019, Molecular Cell, PMID: 30878284

Wang et al., 2017, Immunity, PMID: 28314590

免疫方向博士后

一、崗位職責(zé)

1.參與課題組科研工作，獨(dú)立承擔(dān)相應(yīng)科研課題；

2.協(xié)助課題組長指導(dǎo)研究生實(shí)驗(yàn)；撰寫基金和申報(bào)課題等相關(guān)工作。

二、崗位要求

1.近三年已經(jīng)或即將獲得免疫學(xué)、腫瘤學(xué)、細(xì)胞分子生物學(xué)或其他生物醫(yī)學(xué)領(lǐng)域博士學(xué)位，具有代謝調(diào)控或者抗病毒天然免疫信號(hào)轉(zhuǎn)導(dǎo)研究背景者優(yōu)先；

2.具有扎實(shí)的分子和細(xì)胞生物學(xué)背景，如細(xì)胞培養(yǎng)、基因編輯、流式分析等技術(shù)，在小鼠模型實(shí)驗(yàn)或者生物信息學(xué)（多組學(xué)分析）方面具有較強(qiáng)的專業(yè)技能優(yōu)先；

3.以第一作者身份在領(lǐng)域內(nèi)主流期刊上發(fā)表過或即將發(fā)表研究論文，能夠獨(dú)立開展研究工作，具備高度的科研熱情和嚴(yán)謹(jǐn)?shù)目蒲袘B(tài)度；

4.責(zé)任心強(qiáng)，具有良好的團(tuán)隊(duì)合作精神，具備基本的英文溝通與學(xué)術(shù)寫作能力。

生物信息學(xué)方向博士后

一、崗位職責(zé)

1.參與課題組科研工作，獨(dú)立或合作承擔(dān)相應(yīng)科研課題；

2.協(xié)助課題組長指導(dǎo)研究生,撰寫基金和申報(bào)課題等相關(guān)工作。

二、崗位要求

1.近三年已經(jīng)或即將獲得生物信息學(xué)、計(jì)算生物或系統(tǒng)生物學(xué)等相關(guān)專業(yè)博士學(xué)位,具有表觀遺傳組學(xué)（ChIP-Seq,ATAC-Seq,RNA-seq等）及單細(xì)胞測(cè)序數(shù)據(jù)分析，開發(fā)復(fù)雜生物信息算法或流程的經(jīng)驗(yàn)者優(yōu)先；

2.熟練掌握C++、python或R語言，熟悉Linux操作系統(tǒng)，能夠高效處理與分析大規(guī)模生物數(shù)據(jù)；

3.工作認(rèn)真負(fù)責(zé)，有良好的溝通能力和團(tuán)隊(duì)合作精神；

4.有良好的英語表達(dá)和論文寫作能力。

科研助理

一、崗位職責(zé)

1.參與課題組科研工作，承擔(dān)相應(yīng)科研任務(wù)；

2.負(fù)責(zé)實(shí)驗(yàn)室經(jīng)費(fèi)管理，耗材訂購等工作。

二、崗位要求

1.具有免疫學(xué)、腫瘤學(xué)、細(xì)胞分子生物學(xué)等相關(guān)專業(yè)的本科及以上學(xué)位；

2.掌握常規(guī)分子克隆、細(xì)胞培養(yǎng)的操作原理，有實(shí)驗(yàn)室研究工作經(jīng)歷優(yōu)先；

3.有責(zé)任心和團(tuán)隊(duì)精神，熱愛創(chuàng)新與挑戰(zhàn)；

4.具備基本的英文溝通、寫作能力。

福利待遇

1.根據(jù)應(yīng)聘者的工作經(jīng)驗(yàn)和能力，提供具有市場(chǎng)競爭力的薪酬（詳情面談）；

2.享受五險(xiǎn)一金、帶薪年假、體檢和補(bǔ)充醫(yī)療保險(xiǎn)等；

3.支持個(gè)人職業(yè)發(fā)展，提供必要的工作相關(guān)專業(yè)培訓(xùn)。

申請(qǐng)方法

請(qǐng)將簡歷、個(gè)人陳述（1頁）、2名推薦人的基本信息和聯(lián)系方式、工作總結(jié)與研究興趣（1-2頁，僅限博士后）以及其他申請(qǐng)人認(rèn)為必要的材料，合并為PDF文件發(fā)送至wangyutao@cimrbj.ac.cn，并在郵件主題中注明：“應(yīng)聘博士后/科研助理+本人姓名+所在學(xué)校/單位”，初審?fù)ㄟ^的申請(qǐng)者將會(huì)盡快安排面試 。

聯(lián)系人：王老師

聯(lián)系地址：北京市豐臺(tái)區(qū)右安門外西頭條10號(hào)-首都醫(yī)學(xué)科學(xué)創(chuàng)新中心

本招聘長期有效，至招聘到合適人選為止。

ABOUT CIMR

The Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research. The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment. For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

Dr. Wang’s Laboratory at CIMR is now hiring postdoctoral fellows and research assistants! The lab is dedicated to uncovering the regulatory mechanisms underlying infection, inflammation, and tumor progression, with a particular focus on the nuclear receptor (NR) family in viral infections, cancer immunity, and sex-based differences in immune responses. By integrating small-molecule drug development and synthetic biology approaches, we aim to develop and advance innovative therapeutic strategies for human diseases.

Our group pursues cutting-edge and ambitious scientific projects, backed by a well-equipped research platform, robust funding, and a collaborative, inclusive lab environment. We firmly believe that science makes life better, and we actively encourage open communication, curiosity-driven exploration, and continuous personal and professional growth. Our goal is to balance dedicated research with a fulfilling life. If you're passionate about exploring the frontiers of life science in a supportive and collaborative team, and to grow both professionally and personally, we warmly welcome you to join us!

Dr. Wang received his bachelor’s degree from Lanzhou University and his Ph.D. from Peking University, under the mentorship of Prof. Zhengfan Jiang, where he studied the regulatory mechanisms of the Caspase family in maintaining antiviral innate immune homeostasis and preserving immunological silence during apoptosis. He then completed his postdoctoral training at Harvard Medical School in the laboratory of Drs. Christophe Benoist and Diane Mathis, where he employed an in vivo Rainbow-CRISPR screening system to investigate the roles of nuclear receptors in immune cell differentiation and cell fate decisions. Dr. Wang will officially join the CIMR as an Assistant Investigator in June 2025.

Major Research Projects

a. Exploring the functions of nuclear receptors in viral infection-induced metabolic reprogramming and innate immune responses.

b. Dissecting the functions of nuclear receptors in tumor progression and immune regulation.

c. Uncovering the roles of nuclear receptors in sex-based differences in immune responses.

d. Targeting disease-specific transcriptional activity for precision therapy using synthetic biology approaches.

Major Contributions

a. Developed an innovative in vivo Rainbow-CRISPR screening platform and systematically investigated the nuclear receptor family in the differentiation and homeostatic control of 28 immune cell types, revealing that retinoic acid receptors regulate the fate of GATA6+ large peritoneal macrophages via transcriptional control of cell differentiation and inflammasome-mediated control of cell death (Immunity, 2024, first author).

b. Discovered a novel TRAF6-mediated Lys6-linked polyubiquitination of ASK1, which plays a pivotal role in of hepatic inflammation and fibrosis (Hepatology, 2019，first author); and identified NLK as a key suppressor of hepatic glucose production by inhibiting gluconeogenesis (Cell Metabolism, 2021, first author).

c. Identified the critical roles of the Caspase family in maintaining antiviral innate immune homeostasis and preserving immunological silence during apoptosis (Immunity, 2017, first author; Molecular Cell, 2019, co-first author).

Representative Publications

Wang et al., 2024, Immunity, PMID: 39571575

Ji, Wang et al., 2021, Cell Metabolism, PMID: 33951476

Wang et al., 2020, Hepatology, PMID: 31222801

Ning, Wang et al., 2019, Molecular Cell, PMID: 30878284

Wang et al., 2017, Immunity, PMID: 28314590

Open Positions

Postdoctoral Research Fellow

– Immunology

Main Responsibilities

a. Lead independent research projects and collaborate with lab members.

b. Assist the PI in mentoring graduate students and preparing grant proposals and manuscripts.

Qualifications

a. Ph.D. in immunology, oncology, molecular / cellular biology, or a related biomedical field (obtained within the past three years or expected soon).

b. Solid background in molecular and cellular biology, including cell culture, gene editing, and flow cytometry. Experience with mouse immune-mediated disease models or bioinformatics (e.g., multi-omics analysis) is preferred.

c. Proven track record as first author in high-impact journals or manuscripts under revision; capable of conducting independent research with strong scientific enthusiasm and rigor.

d. Strong responsibility, excellent teamwork and communication skills, and proficient in English communication and scientific writing.

Postdoctoral Research Fellow

– Bioinformatics

Main Responsibilities

a. Lead independent research projects and collaborate with other team members.

b. Assist the PI in mentoring graduate students and preparing grant proposals and manuscripts.

Qualifications

a. Ph.D. in bioinformatics, computational biology, systems biology, or a related field (obtained within the past three years or expected soon); experience in epigenomic data analysis (e.g., ChIP-Seq, ATAC-Seq, RNA-Seq), single-cell sequencing, or development of bioinformatics pipelines/algorithms is highly preferred.

b. Proficient in C++, Python, R, and Linux; capable of processing and analyzing large-scale biological datasets.

c. Highly responsible, self-motivated, with excellent communication skills and a collaborative mindset.

d. Proficient in English communication and scientific writing.

Research Assistant

Main Responsibilities

a. Support research projects independently or in collaboration with lab members.

b. Assist with daily lab operations, including the management of supplies and ordering of reagents.

Qualifications

a. Bachelor’s degree or above in immunology, oncology, molecular and cellular biology, or related fields.

b. Prior research experience in molecular biology and cell culture is preferred.

c. Self-motivated researcher with strong sense of responsibility, good communication skills, and teamwork ability.

d. Basic proficiency in English communication and scientific writing.

Welfare Treatment

a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).

b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c. Support career development, provide relevant professional guidance.

How to apply

Please compile your CV, one-page personal statement, basic information and contact details of two referees and a 1-2 page research summary and interests (for postdoc position only), as well as other materials demonstrating research capabilities into a single PDF file. Send it to wangyutao@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name + University/Employer” in the email subject. Review of applications will begin on a rolling basis, and qualified applicants will be invited for an interview.

Contact person: Dr. Wang

This recruitment is valid for the long term until a suitable candidate is recruited.

信息來源于網(wǎng)絡(luò)，如有變更請(qǐng)以原發(fā)布者為準(zhǔn)。

來源鏈接：

https://mp.weixin.qq.com/s/92Z5m8opHtxcYg9qvrj_zA

為防止簡歷投遞丟失請(qǐng)抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國博士人才網(wǎng)）